Detroit Lions vs. San Francisco 49ers Prediction and Preview

The Detroit Lions (0-1) will make the long trek to the West Coast to face the San Francisco 49ers (0-1) on Sunday at Levi’s Stadium. It's a trip that has not been kind to the visiting Lions in the past. Detroit has lost each of its last 12 games in San Francisco, dating all the way back to 1975.

 

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